Post Reply - H5N1/flu (other types)

   DJ-A major problem with H5N1 is that it is already very widespread around the globe both in birds and mammals...
Rick Bright reposted
Cory
@cramsey
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More bad news on #H5N1 
#Q591R on PB2 has established itself in a lineage in South Dakota beginning in a May sample. Up to 13 descendants, all from cattle in South Dakota. 
Some reading suggests Q591R almost as bad as dreaded E627K:
https://ncbi.nlm.nih.gov/pmc/articles/PMC4249088/…
Seems bad. Experts?

https://ncbi.nlm.nih.gov/pmc/articles/PMC4249088/ or https://ncbi.nlm.nih.gov/pmc/articles/PMC4249088/ ;

Mutations to PB2 and NP Proteins of an Avian Influenza Virus Combine To Confer Efficient Growth in Primary Human Respiratory Cells
Our data show that as few as three mutations, in the PB2 and NP proteins, support robust growth of a low-pathogenic, H1N1 duck isolate in primary human respiratory cells.
DJ A 2014 study...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753988/ or https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753988/ ;
The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage
DJ, H5N1 is moving towards better reproduction in mammals-that is what I (a totally NON-expert !)  make of it...

We are not doing much to stop H5N1...(flu)vaccines may be of limited use...Masks/eyeprotection do offer protection...but when H5N1 starts spreading from mammal to mammal it may become hard to get people to use them...

DJ-Underlying main factor in increase of pandemics is climate collapse..."Politics" kick that can down many roads for decades...Real indications-using 1700-1750 as pre-industrial baseline suggest temperature did increase 2,75C...IPCC still promoting 1,5-2C as a possible limit...

https://arctic-news.blogspot.com/2024/07/the-predicament-of-climate-scientists-on-the-road-to-a-super-tropical-earth.html or https://arctic-news.blogspot.com/2024/07/the-predicament-of-climate-scientists-on-the-road-to-a-super-tropical-earth.html 

Pandemics-including H5N1- are parts of the https://en.wikipedia.org/wiki/Holocene_extinction or https://en.wikipedia.org/wiki/Holocene_extinction 