CoViD in the 1980's ????
Printed From: Mpox Forum
Category: Mpox Discussion Forum:
Forum Name: General Discussion
Forum Description: (General Discussion)
URL: http://www.mpoxforum.com/forum_posts.asp?TID=97
Printed Date: 25 Apr 2025 at 4:18pm
Software Version: Web Wiz Forums 12.07 - https://www.webwizforums.com
Topic: CoViD in the 1980's ????
Posted By: Dutch Josh 2
Subject: CoViD in the 1980's ????
Date Posted: 20 Sep 2024 at 11:30pm
|
https://www.ncf-net.org/what-is-cfids - https://www.ncf-net.org/what-is-cfids or https://www.ncf-net.org/what-is-cfids ; Chronic Fatigue Immune Dysfunction (CFIDS) is also known as Chronic Fatigue Syndrome (CFS) and Myalgic Encephalomyelitis (ME). CFIDS is a disabling condition often affecting the central nervous system, brain, blood, muscles, joints, GI tract and lymph system. Symptoms include disabling fatigue which is not significantly helped by rest, orthostatic intolerance (inability to stand for periods of time), muscle weakness and pain, joint pain, sleep disturbances and un-refreshing sleep, cognitive problems including memory loss and difficulty concentrating, gastro-intestinal problems, headache, fevers and swollen lymph nodes. The goal of the National CFIDS Foundation is to fund science to prove the cause along with a treatment or cure. A portion of all membership dues goes toward this along with all donations with no percentage held back. Although we feel we are close, we will continue to follow up on any leads until our goal is fully met. Important research has already been funded by our all volunteer charity that found a slow decimation of a part of the immune system called Stat-1 which can only be caused by a limited number of viruses and bacteria. Our funding also found the reason why patients had dramatically adverse effects from anesthesia and how to prevent that as well as scientific proof that CFIDS/ME is an autoimmune disease. Our work will continue until the cause has been proven. At that time, we will, gratefully, be able to "go out of existence." What's in a Name?The illness currently called Chronic Fatigue Immune Dysfunction (CFIDS) or Chronic Fatigue Syndrome (CFS) is poorly defined, misunderstood, and controversial while remaining under-funded and under-researched. The names CFIDS and CFS trivialize the illness and subject patients to incredulity and ridicule. The CFS label not only fails to help those with ME, it harms them because treatments considered effective for CFS can make ME patients worse. Simply “renaming” CFS will not solve this problem. Read and sign the https://ncf-net.org/petition.htm - petition we co-sponsor to try to have the United States government recognize the name and case definition of the internationally recognized neurological disease, Myalgic Encephalomyelitis (ME).* DJ, Lots of infectious diseases may see long term health issues...Long CoViD has immunity issues/damage...but it is NOT NEW !!!
|
Replies:
Posted By: Dutch Josh 2
Date Posted: 20 Sep 2024 at 11:36pm
|
https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome - https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome or https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome ; Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling https://en.wikipedia.org/wiki/Chronic_condition - chronic illness . People with ME/CFS experience profound https://en.wikipedia.org/wiki/Fatigue - fatigue that does not go away with rest, sleep issues, and problems with memory or concentration. Further common symptoms include https://en.wikipedia.org/wiki/Dizziness - dizziness , https://en.wikipedia.org/wiki/Nausea - nausea and pain. https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome#cite_note-CDCsym2024-3 - https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome#cite_note-IQWiG-2023-10 - The cause of the disease is unknown. https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome#cite_note-CDC_Clinical2024-11 - https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome#cite_note-Bateman-2021-12 - https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome#cite_note-Dibble_McGrath_Ponting_2020_p.-13 - https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome#cite_note-pmid38443223-14 - https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome#cite_note-pmid37226227-7 - https://en.wikipedia.org/wiki/Myalgic_encephalomyelitis/chronic_fatigue_syndrome - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has a long history with an evolution in medical understanding, diagnoses and social perceptions. In the early 19th century, the diagnosis of https://en.wikipedia.org/wiki/Neurasthenia - neuresthenia was popular, which had overlaps with current ME/CFS criteria. Various outbreaks of enigmatic disease occurred in the early 20th century, variably known as atypical poliomyelitis, https://en.wikipedia.org/wiki/Akureyri_disease - Akureyri disease or epidemic neuromyasthenia. After an outbreak in the Royal Free Hospital in London, the disease became known as benign myalgic encephalomyelitis. Controversy erupted when psychiatrists who had not spoken to any of the patients called the outbreak a case of "mass hysteria". The first case definition of ME was published in 1986, and the first definition of CFS in 1988. DJ, If "science" is unable to detect (any longer) a cause for disease-or clear "problems" they tend to go for claiming it is a mental issue...Untill also lots of medical workers catch it...
|
Posted By: Dutch Josh 2
Date Posted: 20 Sep 2024 at 11:44pm
|
DJ-There have been "reports" of ME-CFS for over 200 years...describing symptoms but hardly any science involved... https://en.wikipedia.org/wiki/History_of_ME/CFS#Case_definitions_%281986_onwards%29 - https://en.wikipedia.org/wiki/History_of_ME/CFS#Case_definitions_(1986_onwards) or https://en.wikipedia.org/wiki/History_of_ME/CFS#Case_definitions_(1986_onwards) ; The illness gained national attention in the United States when the popular magazine Hippocrates ran a cover story of an epidemic at https://en.wikipedia.org/wiki/Lake_Tahoe - Lake Tahoe , https://en.wikipedia.org/wiki/Nevada - Nevada , in the mid-1980s. https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-OslersWeb-34 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-pmid2578266-35 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-pmid2578268-36 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-Hippocrates-37 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-isbn0-19-263049-0-38 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-isbn0801879426-39 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-Holmes1988-40 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-41 - In 1990, researchers presented evidence they found https://en.wikipedia.org/wiki/DNA - DNA sequences very similar to the human https://en.wikipedia.org/wiki/HTLV-II - HTLV-II retrovirus in some CFS patients, at a conference in https://en.wikipedia.org/wiki/Kyoto,_Japan - Kyoto, Japan . https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-DOI_10.1126-42 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-NYT-43 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-pmid_1672770-44 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-PTL-45 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-Retroviral-46 - In the United Kingdom, the https://en.wikipedia.org/wiki/Chief_Medical_Officer - Chief Medical Officer https://en.wikipedia.org/wiki/Kenneth_Calman - Kenneth Calman requested a report from the medical Royal Colleges in 1996. This led to the publication of a joint report in which the term "chronic fatigue syndrome" was found to be most representative. https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-47 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-CMOrept2002-48 - The U.S. https://en.wikipedia.org/wiki/Centers_for_Disease_Control_%26_Prevention - Centers for Disease Control & Prevention (CDC) recognize CFS as a serious illness, and launched a campaign in June 2006 to raise public and medical awareness about it. https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-CDCBasic-49 - https://en.wikipedia.org/wiki/History_of_ME/CFS#cite_note-CDC-awareness-50 - |
Posted By: Dutch Josh 2
Date Posted: 22 Sep 2024 at 1:29am
|
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full - https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full or https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full Front. Med., 02 June 2023 ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people housebound and disabled. The illness (Long COVID) is similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well as to persisting illnesses that can follow a wide variety of other infectious agents and following major traumatic injury. Together, these illnesses are projected to cost the U.S. trillions of dollars. In this review, we first compare the symptoms of ME/CFS and Long COVID, noting the considerable similarities and the few differences. We then compare in extensive detail the underlying pathophysiology of these two conditions, focusing on abnormalities of the central and autonomic nervous system, lungs, heart, vasculature, immune system, gut microbiome, energy metabolism and redox balance. This comparison highlights how strong the evidence is for each abnormality, in each illness, and helps to set priorities for future investigation. The review provides a current road map to the extensive literature on the underlying biology of both illnesses. DJ, Health stories SHOULD be about avoiding/limiting suffering...however in the present brutal reality "costs matter more than humans"... In this review, we compare the symptoms of Long COVID and ME/CFS, noting considerable similarities and some differences. Early in the study of both illnesses, the lack of objective biomarkers led some to question whether the illnesses were “real”—whether people might be imagining or even fabricating their symptoms. In this review we summarize the emerging evidence that, in fact, there are many underlying biological abnormalities reported in both illnesses, documented by multiple laboratories. Moreover, we show that the two illnesses share many of these underlying abnormalities, just as they share many symptoms. That is, both illnesses are “real,” and both share similar biological abnormalities. Understanding the underlying biology of these illnesses is critically important, given the burden they are placing on all societies. The National Academy of Medicine and Centers for Disease Control and Prevention (CDC) estimate that, in the U.S., ME/CFS affects up to 2.5 million people and generates direct and indirect expenses of approximately $17–24 billion annually ( https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full#B1 - 1 ). It also has been reported in many countries around the world. - Myalgic encephalomyelitis/CFS often, but not always, follows in the wake of an apparent “infectious-like” illness characterized by respiratory and gastrointestinal symptoms, fatigue, myalgias and other symptoms as well as fever and lymphadenopathy ( https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full#B518 - 518 ). This “infectious-like” illness often is little different, initially, from the common, transient infectious illnesses that most people experience throughout life. It is not standard medical practice to test for the responsible infectious agent in people with common and transient infectious illnesses. Thus, typically no testing has been done to determine the cause of the initial “infectious-like” illness that then becomes a chronic illness in subsequent months and years. DJ, ME-CFS (etc) does not go away...lots of people suffer from it for decades...From that perspective realism may give Long CoViD patients an idea of what to expect. "Graded excercise" etc. can help to "optimize capabilities"....full recovery however is not very likely. This realism may be hard to swallow-however it should be used to provide lots of L.C. patients both (mental) support and an income...
|
Posted By: Dutch Josh 2
Date Posted: 22 Sep 2024 at 1:52am
|
part 2 ( https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full - https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full or https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full ) Attempts to identify a single and possibly novel infectious agent as the cause of most cases of ME/CFS have been unsuccessful. For example, claims that murine leukemia viruses cause ME/CFS have been refuted ( https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full#B528 - 528 , https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full#B529 - 529 ), as have similar claims for Borna disease virus ( https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full#B530 - 530 ). DJ- https://en.wikipedia.org/wiki/Common_cold - https://en.wikipedia.org/wiki/Common_cold or https://en.wikipedia.org/wiki/Common_cold ; The common cold or the cold is a https://en.wikipedia.org/wiki/Virus - viral https://en.wikipedia.org/wiki/Infectious_disease - infectious disease of the https://en.wikipedia.org/wiki/Upper_respiratory_tract - upper respiratory tract that primarily affects the https://en.wikipedia.org/wiki/Respiratory_epithelium - respiratory mucosa of the https://en.wikipedia.org/wiki/Human_nose - nose , https://en.wikipedia.org/wiki/Throat - throat , https://en.wikipedia.org/wiki/Paranasal_sinuses - sinuses , and https://en.wikipedia.org/wiki/Larynx - larynx . https://en.wikipedia.org/wiki/Common_cold#cite_note-CMAJ2014-6 - https://en.wikipedia.org/wiki/Common_cold#cite_note-CE11-8 - https://en.wikipedia.org/wiki/Common_cold#cite_note-CMAJ2014-6 - https://en.wikipedia.org/wiki/Common_cold#cite_note-CDC2015-3 - https://en.wikipedia.org/wiki/Common_cold#cite_note-Eccles2005-4 - https://en.wikipedia.org/wiki/Common_cold#cite_note-CDC2015-3 - https://en.wikipedia.org/wiki/Common_cold#cite_note-Heik2003-7 - https://en.wikipedia.org/wiki/Common_cold#cite_note-CDC2015-3 - Well over 200 https://en.wikipedia.org/wiki/Virus_strain - virus strains are implicated in causing the common cold, with https://en.wikipedia.org/wiki/Rhinovirus - rhinoviruses , https://en.wikipedia.org/wiki/Coronavirus - coronaviruses , https://en.wikipedia.org/wiki/Adenoviridae - adenoviruses and https://en.wikipedia.org/wiki/Enterovirus - enteroviruses being the most common. https://en.wikipedia.org/wiki/Common_cold#cite_note-14 - |
Posted By: Dutch Josh 2
Date Posted: 11 Oct 2024 at 8:33am
|
https://x.com/tmprowell - https://x.com/tmprowell - < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Researchers exposed skeletal muscle to serum from ppl w/ https://x.com/hashtag/MECFS?src=hashtag_click - #MECFS or https://x.com/hashtag/LongCovid?src=hashtag_click - #LongCovid
https://x.com/48 - @48 hrs : contractile
profile severely compromised, shift to glycolysis
@ 96-144 hrs: high fatiguability, fragile tissue, fragmented mitochondria
https://x.com/hashtag/MedTwitter?src=hashtag_click - #MedTwitter , PEM is real. link; https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 - https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 or https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 ; Prolonging the exposure to 96 and 144 hours induced high fatiguability, and fragility in tissues. The mitochondria, at longer exposures, appeared to be fragmented and assumed a toroidal conformation indicating a change in mitochondrial membrane potential. We hypothesize that the disease progresses through an intermediary stress-induced hypermetabolic state, ultimately leading to severe deterioration of muscle function. This is the first account of research that proposes acquired metabolic plasticity in 3D skeletal muscles exposed to ME/CFS and Long COVID-19 sera. -DJ-The conclusion -my view- pushing people with ME-CFS/Long CoViD beyond their limits brings serious damage... https://x.com/tmprowell - https://x.com/tmprowell - · https://x.com/tmprowell/status/1844132020278218797 - To be clear for anyone new to my posts, this study isn’t when I decided post-exertional malaise (PEM) is real. Many people w/ https://x.com/hashtag/MECFS?src=hashtag_click - #MECFS & https://x.com/hashtag/LongCovid?src=hashtag_click - #LongCovid have described severe fatigue & said exertion worsens symptoms, sometimes dramatically. Listen to patients. Believe them. https://x.com/hashtag/MedTwitter?src=hashtag_click - #MedTwitter -
|
Posted By: Dutch Josh 2
Date Posted: 12 Oct 2024 at 9:17am
|
https://www.thailandmedical.news/news/study-finds-that-long-covid-19-patients-exhibit-impaired-fat-oxidation - https://www.thailandmedical.news/news/study-finds-that-long-covid-19-patients-exhibit-impaired-fat-oxidation or https://www.thailandmedical.news/news/study-finds-that-long-covid-19-patients-exhibit-impaired-fat-oxidation link to https://www.sciencedirect.com/science/article/pii/S0261561424003686 - https://www.sciencedirect.com/science/article/pii/S0261561424003686 or https://www.sciencedirect.com/science/article/pii/S0261561424003686 ; Analysis of fat oxidation capacity during cardiopulmonary exercise testing indicates long-lasting metabolic disturbance in patients with Post-COVID-19 SyndromeDJ, This study did find https://en.wikipedia.org/wiki/Mitochondrion - https://en.wikipedia.org/wiki/Mitochondrion or https://en.wikipedia.org/wiki/Mitochondrion did not function the way they should in Long CoViD cases...A fitting excercise plan did bring improvement... It reminds me of the discussion also in ME-CFS cases; Do people "optimize" or recover ? It may be effective for some groups-age/gender linked...?
|
Posted By: Dutch Josh 2
Date Posted: 01 Jan 2025 at 8:37am
|
https://x.com/drseanmullen/status/1873867049585549552 - https://x.com/drseanmullen/status/1873867049585549552 or https://x.com/drseanmullen/status/1873867049585549552; https://x.com/HarrySpoelstra - https://x.com/drseanmullen">  https://x.com/drseanmullen - - https://x.com/drseanmullen - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Cognitive Dysfunction in Long Covid: What You Need to Know
This paper dives deep into the complexities of cognitive dysfunction in people with Long COVID—what many call “brain fog” but what is actually a much more debilitating symptom. It’s not just about forgetting where you left your keys; it’s about struggling to work, parent, or even read without triggering post-exertional symptom exacerbation (PESE)—a worsening of symptoms after even minor physical, cognitive, or emotional effort.
Key Insights for Patients and Practitioners:
1. Cognitive Dysfunction is Overlooked and Episodic/Relapse-remitting - Standardized tests often miss the episodic nature of cognitive issues. Patients may appear fine in a controlled setting but struggle with real-world challenges like work or parenting. This is critical to understand for healthcare providers assessing these symptoms.
2. Cognitive Activity Can Trigger PESE - Unlike traditional rehabilitation, cognitive tasks like reading or attending a meeting can trigger a severe, delayed crash in symptoms. Cognitive PESE isn't caused by “deconditioning” but likely involves **neuroinflammation, vascular damage, or viral persistence.
3. Occupational Therapy (OT) Offers Hope - OTs are uniquely positioned to help through cognitive pacing, a strategy to balance mental workload with rest. This involves tailoring tasks to the individual, considering factors like time of day, task complexity, and even body positioning to improve blood flow to the brain. (That said, most OTs aren’t trained in brain training principles and applications to target specific weaknesses, something there is a certification for & I believe it’s necessary to complete claim one is remotely competent in this area)
4. Parallels with ME/CFS - The authors highlight the similarities between Long Covid and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The hallmark symptom—PESE—demands energy management over “pushing through.” This flies in the face of typical rehabilitation models.
Clinical Takeaways:
- Cognitive pacing is a cornerstone of care. Strategies include journaling, biofeedback (e.g., heart rate monitoring), and modifying daily routines to prevent overexertion.
- Patient-led adaptations are essential. Many people with Long Covid have already developed coping strategies like breaking tasks into chunks or limiting multitasking. OT can refine and support these.
Why This Matters
Cognitive dysfunction doesn’t just steal moments of clarity—it robs people of their roles and identities. Parenting, working, or even driving becomes impossible without worsening symptoms. This isn’t laziness or lack of willpower; it’s a physiological reality backed by research showing changes in brain structure, blood flow, and inflammatory markers.
A Note from Me
As a health behavior scientist and advocate for safe rehabilitation, this hits home. While exercise and cognitive training are my bread and butter, they must be approached with extreme caution in conditions like Long Covid and ME/CFS. This paper reinforces what patients have been saying for years (decades): rehabilitation without understanding PESE does more harm than good. The focus needs to shift from “fixing” to listening and supporting.
If we’re going to move the needle on recovery, research and clinical practice need to keep pace with what patients already know—rest, pacing, and careful scaffolding are key. - https://x.com/GendlinsMuse - https://x.com/GendlinsMuse - · https://x.com/GendlinsMuse/status/1873970268018008120 - Thanks for the summary. Very helpful. Have you seen any papers about ADHD and https://x.com/hashtag/LongCovid?src=hashtag_click - #LongCovid ? My colleagues tell me that ADHD can worsen, even in previously stabilized clients (with meds/therapy). DJ, What may work well for one person with L.C/M.E may not help another. In part related to the damage virus infection(s) did. |
Posted By: Dutch Josh 2
Date Posted: 27 Jan 2025 at 12:39pm
|
https://x.com/CoRESinai/status/1883877681810256122 - https://x.com/CoRESinai/status/1883877681810256122 or https://x.com/CoRESinai/status/1883877681810256122 ; https://x.com/CoRESinai - https://x.com/CoRESinai - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> We are investigating the presence of certain bacteria in the blood samples of people who have either https://x.com/hashtag/LongCOVID?src=hashtag_click - #LongCOVID , Chronic https://x.com/hashtag/TickBorne?src=hashtag_click - #TickBorne and https://x.com/hashtag/VectorBorne?src=hashtag_click - #VectorBorne Illnesses, https://x.com/hashtag/MECFS?src=hashtag_click - #MECFS , or https://x.com/hashtag/EDS?src=hashtag_click - #EDS . Our clinical trial is currently recruiting! Putrino Lab @PutrinoLab · We are seeing some really interesting results in this trial. It has the potential to answer some crucial questions about relationships between fibrin production and the symptoms of #LongCOVID, #MECFS, and chronic #lyme disease. If you have one of these diagnoses, plz reach out! x.com/CoRESinai/stat… core@mountsinai.org https://x.com/CoRESinai/status/1883877681810256122/photo/1 - https://x.com/CoRESinai/status/1883877681810256122/photo/1 - https://x.com/CoRESinai/status/1883877681810256122/photo/1 - https://x.com/CoRESinai/status/1883877681810256122/photo/1 - https://x.com/CoRESinai/status/1883877681810256122/photo/1 or https://x.com/CoRESinai/status/1883877681810256122/photo/1 https://x.com/CoRESinai/status/1883877681810256122 - 1,940 ViewsDJ
|
Posted By: Dutch Josh 2
Date Posted: 01 Feb 2025 at 11:28pm
|
https://x.com/Med58ll">  https://x.com/Med58ll - https://x.com/Med58ll - < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> Uit een onderzoek onder 220 ME/CVS-patiënten bleek dat 75% verbetering had na intraveneuze Remdesivir en 52% na Paxlovid, waarbij de effecten weken tot maanden aanhielden voordat er een terugval ontstond. < aria-expanded="true" aria-label="Hide translated post" role="" ="-1jxf684 r-bcqeeo r-qvutc0 r-poiln3 r-n6v787 r-1cwl3u0 r-1loqt21 r-fdjqy7" ="" style="text-align: left; font-size: 13px; font-family: inherit; color: rgb29, 155, 240; border-width: 0px; border-style: solid; border-color: black; display: inline; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: 16px; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; list-style: none; margin: 0px; padding: 0px; : relative; white-space: inherit; overflow-wrap: break-word; cursor: pointer; min-width: 0px;">Translated from Dutch by https://translate.google.com/ - link; https://academic.oup.com/ofid/article/12/Supplement_1/ofae631.2514/7988721?login=false - https://academic.oup.com/ofid/article/12/Supplement_1/ofae631.2514/7988721?login=false or https://academic.oup.com/ofid/article/12/Supplement_1/ofae631.2514/7988721?login=false ;Background Etiology remains elusive for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and no treatment exists. Antivirals had no efficacy in randomized clinical trials (RCT) for Epstein-Barr Virus and HHV-6. Enteroviruses (EV) have been implicated, but no antivirals are available. Many patients who received SARS–CoV-2-specific antiviral drugs for acute Covid-19 (COV19) infection experienced significant improvement of prior ME/CFS symptoms. This study summarizes their responses to antivirals for SARS-Cov-2. - Results 15/20 (75%) ME/CFS patients – 10/12 hospitalized, 5/8 non-COV19 patients – responded to IV Rem 2-6 weeks after infusions; remission lasted 6-8 weeks to 6-9 months before relapse. Of Controls: 2/20 had mild improvement (< 0.001, X 2 ). 104/200 (52%) of PAX-treated ME/CFS patients improved, often within 2-3 days; all relapsed within days to weeks after treatment. 66%, 33% and 44% of CVB4+, CVB3+, non-CVB3,4+ patients responded to treatment, respectively. EVP decreased and increased with clinical response and relapse. Conclusion Rem and PAX demonstrated clinical efficacy in ME/CFS patients with chronic enterovirus infections. Placebo-controlled RCT will be needed to clarify the role of antivirals in ME/CFS. DJ, Indicating ME-CFS-like Long CoViD may be a form of chronic viral infection (with other infections sometimes on top; bacterial, fungal).
|
Posted By: Dutch Josh 2
Date Posted: 14 Feb 2025 at 7:39am
|
https://x.com/Med58ll - https://x.com/vipintukur">  https://x.com/vipintukur - https://x.com/vipintukur - < aria-label="Grok s" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> < aria-expanded="false" aria-haspopup="menu" aria-label="More" role="" ="-175oi2r r-1777fci r-bt1l66 r-bztko3 r-lrvibr r-1loqt21 r-1ny4l3l" -testid="caret" ="" style="text-align: inherit; font-size: inherit; font-family: inherit; align-items: stretch; border-width: 0px; border-style: solid; border-color: black; display: flex; flex-basis: auto; flex-direction: column; flex-shrink: 0; list-style: none; margin: 0px; min-height: 20px; min-width: 0px; padding: 0px; : relative; : 0; overflow: ; justify-: center; cursor: pointer; outline-style: none; user-: none;"> How https://x.com/hashtag/LongCovid?src=hashtag_click - #LongCovid impacts brain structure!
A NEW study shows that striking brain similarities, in particular, a larger than normal hippocampus, have been detected in patients who experience https://x.com/hashtag/LongCovid?src=hashtag_click - #LongCovid & Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). 1/ - https://x.com/vipintukur - https://x.com/vipintukur - · https://x.com/vipintukur/status/1889524252690538947 - Researchers focused on using specific MRI machine to study the brain in these participants to determine similarities in particular areas of the brain, such as the hippocampus, which plays a critical role in controlling memory and cognition 2/ - https://x.com/vipintukur - https://x.com/vipintukur - · https://x.com/vipintukur/status/1889526150562718144 - MRI identified significantly larger hippocampal volume in long
COVID & ME/CFS patients compared to healthy individuals without these conditions.
Furthermore, the study showed similar hippocampal volume in patients, emphasizing striking brain similarities between the two 3/ - https://x.com/vipintukur - https://x.com/vipintukur - · https://x.com/vipintukur/status/1889526307933098137 - "The research also reported the hippocampal volume was associated with symptom severity in both patient groups. 4/ - https://x.com/vipintukur - https://x.com/vipintukur - · https://x.com/vipintukur/status/1889526404401811641 - Therefore, hippocampal impairment in long COVID and ME/CFS patients may play a significant role in cognitive difficulties such as memory problems, difficulty concentrating, and delayed responses to questions or conversations. 5/ - https://x.com/vipintukur - https://x.com/vipintukur - · https://x.com/vipintukur/status/1889526660707524805 - Larger hippocampal volume could be due to neurogenesis, the formation of new neurons, or a virus in the brain. 6/6 link; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316625 - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316625 or https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316625
|
Posted By: Dutch Josh 2
Date Posted: 20 Feb 2025 at 2:39am
|
DJ, The Netherlands had a very major Q-fever outbreak around 20 years ago... https://www.omroepbrabant.nl/nieuws/4644769/veel-meer-chronische-q-koortspatienten-zonder-dat-ze-het-zelf-weten - https://www.omroepbrabant.nl/nieuws/4644769/veel-meer-chronische-q-koortspatienten-zonder-dat-ze-het-zelf-weten or https://www.omroepbrabant.nl/nieuws/4644769/veel-meer-chronische-q-koortspatienten-zonder-dat-ze-het-zelf-weten ; Possibly hundreds of people chronically ill without diagnosis According to interest group Q-support, about six hundred people have so far been diagnosed with chronic Q fever (see box). But there may still be four hundred to sixteen hundred people who walk around with the same disease without a diagnosis. - The turnout for the population screening was very low. About half of the GP practices in the regions participated. They invited only a small proportion of their patients, and less than half of them ultimately accepted the invitation. According to Q-support, this is due to a lack of time among GPs, but also 'due to a lack of knowledge about Q fever'. DJ, Chronic Q-fever may increase risks for other infections...Diseases around goat/sheep farms still are higher. Retrospective it may be very hard to find out what disease(s) did cause chronic healthissues. Statistics (models) may (at best- give an indication.
|
Posted By: Dutch Josh 2
Date Posted: 14 Mar 2025 at 4:15am
|
https://www.thailandmedical.news/news/high-prevalence-of-epstein-barr-virus-and-other-viral-markers-found-in-patients-with-chronic-fatigue-syndrome - https://www.thailandmedical.news/news/high-prevalence-of-epstein-barr-virus-and-other-viral-markers-found-in-patients-with-chronic-fatigue-syndrome or https://www.thailandmedical.news/news/high-prevalence-of-epstein-barr-virus-and-other-viral-markers-found-in-patients-with-chronic-fatigue-syndrome link to https://www.preprints.org/manuscript/202502.0185/v3 - https://www.preprints.org/manuscript/202502.0185/v3 or https://www.preprints.org/manuscript/202502.0185/v3 ;
|